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SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.6
USERS' SCORE
Excellent
Based on 33 Reviews
9
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9
Zinc shortens cold duration variability
Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration.
Direct effect on cold duration
We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.
Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.
Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.
Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.
Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.
Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.
Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.
Read More
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Highly relevant vitamin D study
We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
Read More
8
Vitamin D3 aids cold recovery
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Highly relevant to respiratory health
We explored whether taking 25-hydroxyvitamin D3, a form of vitamin D, could have a positive impact on upper respiratory tract infections (URTIs), commonly known as colds. To do this, we conducted a randomized, double-blind, placebo-controlled study at clinics in Japan, involving 428 participants aged between 45 and 74 years.
Participants were divided into two groups: one received a daily dose of 10 micrograms of vitamin D3, while the other group received a placebo for 16 weeks. We monitored the frequency of URTIs, their severity, the participants’ quality of life, and the duration of the infections.
Our findings revealed that those who took vitamin D3 experienced shorter durations of URTIs, less severe symptoms, and better quality of life during their illness compared to those on the placebo. This suggests that vitamin D3 may help mitigate the discomfort associated with colds and potentially make us feel better more quickly when we are sick.
Participants were divided into two groups: one received a daily dose of 10 micrograms of vitamin D3, while the other group received a placebo for 16 weeks. We monitored the frequency of URTIs, their severity, the participants’ quality of life, and the duration of the infections.
Our findings revealed that those who took vitamin D3 experienced shorter durations of URTIs, less severe symptoms, and better quality of life during their illness compared to those on the placebo. This suggests that vitamin D3 may help mitigate the discomfort associated with colds and potentially make us feel better more quickly when we are sick.
Read More
Most Useful Reviews
9.5
Relieved cold symptoms
The addition of vitamin D3 to calcium, magnesium, and zinc makes this supplement effective. My teeth no longer ache, and I no longer experience bone crunching. This complex supports my overall wellness.
Read More
9.5
Quick cold recovery
After feeling unwell, I took this product and my cold improved remarkably in just a few days. It significantly boosted my wellbeing without needing other medications.
Read More
9.5
Supports during colds
An excellent complex to support the body during a common cold. It’s highly effective when needing extra support.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.6
9
Zinc's potential in virus treatment
Inhibition of Respiratory RNA Viruses by a Composition of Ionophoric Polyphenols with Metal Ions.
Zinc's effect combined, not isolated
We explored the effectiveness of zinc in combination with herbal polyphenols against respiratory RNA viruses, including the common cold. In this study, the researchers combined zinc picolinate with various flavonoids to see if it could reduce viral replication and load without harming healthy cells.
The results were quite promising, showing a significant reduction of 50-95% in the genome replication levels of viruses like the human coronavirus OC43, influenza A virus, and human metapneumovirus. This suggests that zinc, when paired with appropriate compounds, may play a beneficial role in treating infections that lead to the common cold.
However, it's important to note that while the study shows a notable decrease in viral activity, it did not specifically isolate the effects of zinc alone. Thus, we cannot definitively state that zinc by itself is effective against the common cold without considering the contributions of the other substances involved.
Overall, this research opens the door for developing a potential treatment that is not toxic and sourced from natural ingredients, which could be effective against various RNA viruses with the hope of remaining effective even amidst mutating strains.
The results were quite promising, showing a significant reduction of 50-95% in the genome replication levels of viruses like the human coronavirus OC43, influenza A virus, and human metapneumovirus. This suggests that zinc, when paired with appropriate compounds, may play a beneficial role in treating infections that lead to the common cold.
However, it's important to note that while the study shows a notable decrease in viral activity, it did not specifically isolate the effects of zinc alone. Thus, we cannot definitively state that zinc by itself is effective against the common cold without considering the contributions of the other substances involved.
Overall, this research opens the door for developing a potential treatment that is not toxic and sourced from natural ingredients, which could be effective against various RNA viruses with the hope of remaining effective even amidst mutating strains.
Read More
9
Zinc shortens cold duration variability
Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration.
Direct effect on cold duration
We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.
Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.
Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.
Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.
Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.
Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.
Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.
Read More
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Highly relevant vitamin D study
We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
Read More
8
Vitamin D’s role in cold prevention
Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds.
Moderate relevance to vitamin D
We examined the role of vitamin D in managing common colds, delving into how it interacts with our immune system to potentially lessen the severity and duration of symptoms. The study highlighted that individuals with vitamin D deficiency, as well as those not receiving large doses, are more likely to benefit from vitamin D supplementation during cold episodes.
Findings suggest that vitamin D might act as a protective agent against common colds overall. Taking vitamin D regularly could help fortify our immune response, which plays a crucial part in fighting off the viruses responsible for colds. The research points towards the idea that maintaining adequate vitamin D levels may offer significant advantages for keeping our immune system vigilant.
However, it’s essential to approach this information with a measure of caution, as further research is necessary to draw definitive conclusions. Overall, encouraging patients to consider vitamin D as a part of their cold prevention strategy seems promising.
Findings suggest that vitamin D might act as a protective agent against common colds overall. Taking vitamin D regularly could help fortify our immune response, which plays a crucial part in fighting off the viruses responsible for colds. The research points towards the idea that maintaining adequate vitamin D levels may offer significant advantages for keeping our immune system vigilant.
However, it’s essential to approach this information with a measure of caution, as further research is necessary to draw definitive conclusions. Overall, encouraging patients to consider vitamin D as a part of their cold prevention strategy seems promising.
Read More
8
Vitamin D3 aids cold recovery
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Highly relevant to respiratory health
We explored whether taking 25-hydroxyvitamin D3, a form of vitamin D, could have a positive impact on upper respiratory tract infections (URTIs), commonly known as colds. To do this, we conducted a randomized, double-blind, placebo-controlled study at clinics in Japan, involving 428 participants aged between 45 and 74 years.
Participants were divided into two groups: one received a daily dose of 10 micrograms of vitamin D3, while the other group received a placebo for 16 weeks. We monitored the frequency of URTIs, their severity, the participants’ quality of life, and the duration of the infections.
Our findings revealed that those who took vitamin D3 experienced shorter durations of URTIs, less severe symptoms, and better quality of life during their illness compared to those on the placebo. This suggests that vitamin D3 may help mitigate the discomfort associated with colds and potentially make us feel better more quickly when we are sick.
Participants were divided into two groups: one received a daily dose of 10 micrograms of vitamin D3, while the other group received a placebo for 16 weeks. We monitored the frequency of URTIs, their severity, the participants’ quality of life, and the duration of the infections.
Our findings revealed that those who took vitamin D3 experienced shorter durations of URTIs, less severe symptoms, and better quality of life during their illness compared to those on the placebo. This suggests that vitamin D3 may help mitigate the discomfort associated with colds and potentially make us feel better more quickly when we are sick.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 33 Reviews
9
9.5
Relieved cold symptoms
The addition of vitamin D3 to calcium, magnesium, and zinc makes this supplement effective. My teeth no longer ache, and I no longer experience bone crunching. This complex supports my overall wellness.
9.5
Quick cold recovery
After feeling unwell, I took this product and my cold improved remarkably in just a few days. It significantly boosted my wellbeing without needing other medications.
9.5
Supports during colds
An excellent complex to support the body during a common cold. It’s highly effective when needing extra support.
9.5
Strengthens bones
The composition is superb for maintaining health and combating colds. It reduces osteoporosis risk and is easy to consume with just one tablet daily. Highly recommended for my age group!
9.5
Warm extremities benefit
Taking this supplement before bed has eliminated my cold hands and feet! Despite taking a multivitamin every morning, I needed calcium and magnesium. The included vitamin D aids in calcium absorption, and I was pleasantly surprised to wake up with warm hands and feet. I feel rejuvenated!
Read More
